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Interestingly, the tesofensine-treated rats also had lower levels of dopamine receptors in certain brain regions compared to both the placebo-treated rats and the rats on a restricted diet

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Antihypertrophic effect of Na+/H+ exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species

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The dose escalation phase matters significantly for nausea timing