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J Clinic Investigat

Others who might be prescribed B12 shots are those at the highest risk for a B12 deficiency, including: Vegans, since vitamin B12 is found only in animal products People ages 60 and up since their bodies don't absorb B12 as efficiently People with Crohn's disease or pancreatic disease, since they prevent nutrient absorption People who had weight-loss surgery, which decreases B12 absorption People with an eating disorder People with HIV People with diabetes Since a mild B12 deficiency might not cause symptoms, it can go undetected for years since levels are not checked during routine blood work

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Deleting IGF-IR at the stage of osteoprogenitor development by Cre-lox recombination using an osterix promoter-driven Cre mouse line, results in delayed osteoblast maturation, matrix synthesis and mineralization, without affecting the differentiation or function of osteoclasts (57)