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Exercise helps to reduce inflammation and cortisol levels, while getting adequate sleep helps regulate hormones like melatonin and cortisol

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

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