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The resulting particles were subjected to non-uniform 3D refinement, followed by a final local Euler angle local refinement to generate the final consensus maps from which the -helical domain (AHD) of the G s protein and the detergent micelle were masked out

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of subjects CL/f=Total body clearance after oral dosing Vd/f=Volume of distribution calculated after oral dosing These data indicate that glimepiride did not accumulate in serum, and the pharmacokinetics of glimepiride were not different in healthy volunteers and in Type 2 diabetic patients

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