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Association of serum adiponectin levels with artherosclerosis and the metabolic syndrome in obese children
However, the available human research is limited, and controlled clinical trials have not demonstrated consistent or substantial benefits
Human trials also report improvements in cholesterol levels, liver enzymes, and blood pressure, which are closely tied to excess weight and long-term metabolic strain
The FDA may take certain actions with respect to Breakthrough Therapies, including holding meetings with the sponsor throughout the development process
doi: 10.1016/S1473-3099(14)70852-7 24 ThwaitesGETranTH
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