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The prostate gland exhibits unique metabolic features characterized by extraordinary citrate production (up to 180 mM in prostatic fluid) to support sperm energetics, sustained through zinc-mediated inhibition of mitochondrial aconitase(m-ACNT), which blocks citrate-to-isocitrate conversion (71)

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These findings suggest that UA supplementation enhances bone density, hardness, and stiffness, resulting in stronger, more resilient bones with denser trabecular architecture, thereby better balancing internal bone forces

CNS effect: Decreases hypothalamic neurons by suppressing AMPK

Peterson, James J