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Materials and methods Drugs and chemicals Powdered L-PAM and BSO (DL buthionine-( S,R )-sulfoximine) were purchased from Sigma-Aldrich (St Louis, MO, USA) and clinical grade BSO (L-buthionine ( S,R )-sulfoximine (50 mg/ml)) was provided by the National Cancer Institute (Bethesda, MD, USA)

discussion 143S-146S

[DOI] [PMC free article] [PubMed] [Google Scholar] 124.Huss M., Vlp A., Stauss-Grabo M

Why the Field Still Lacks Mechanistic Clarity The inability to establish a reproducible mechanistic model does not reflect a deficit of data, intelligence, or investment