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Unlike most nutrients, B12 requires a protein called intrinsic factor (IF) to be absorbed

In a trial of patients with T2DM and BMI 27 kg/m2 or more receiving semaglutide injection for weight management, retinal disorders were reported by 6.9% of patients treated with semaglutide 2.4 mg/week, 6.2% of patients treated with semaglutide 1 mg/week, and 4.2% of patients treated with placebo

Online reports cannot establish causation because the material may be mislabelled, contaminated, combined with other substances or used without objective monitoring

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FDA described insufficient clinical safety information, characterisation concerns and inadequate evidence of effectiveness for its reviewed use