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For patients with bi-allelic mutations in POMC , LEPR , or MC4R [45] , bariatric surgery achieved only limited long-term weight loss, with all patients experiencing significant weight regain after initial weight reduction

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elegans has given us many insights into the genetic regulation of aging and mitochondrial function, and it has provided us with a vast array of mutants to study these effects (Tsang and Lemire, 2003

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Alanine (Ala), the smallest chiral amino acid, serves as an ideal probe for alanine-scanning mutagenesis (Figure S2)