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Therefore, one of the main methods of desensitizing cells to ferroptosis may be inhibiting ACSL4 expression, which is controlled by a number of signalling pathways [35, 36].Conversely, increased ACSL4 expression may contribute to ferroptosis in various pathophysiological settings [37, 38]

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Freemans work led directly to the development of a successful strategy for cancer immunotherapy - blocking the PD-1-ligand interaction

Increasing the dose might work but adds risk