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STAT3: Signal Transducer and Activator of Transcription 3

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The observed gender differences in nicotine craving reductions indicate that female participants were significantly more likely to report reduced nicotine cravings compared with males, a finding that remained significant after adjustment for potential confounders (adjusted odds ratio [aOR] 0.27 for males vs females, 95% CI 0.120.61

Therefore, dose adjustment is necessary in preclinical animal models

Some individuals may experience side effects that could temporarily impact their concentration and reaction times