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The cardiac pathology seen in these dogs is typical of positive inotropic drug toxicity in normal dog hearts, and is related to the physiologic effect of the drug on contractility and exaggerated hemodynamic response." On Vetmedin's website, it has this warning: "The safety of VETMEDIN has not been established in dogs with asymptomatic heart disease." RETURN TO TOP January 30, 2011: Chiari-like malformation HAS been re-defined

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Differences in the outcomes reported across these CVOTs makes comparisons difficult, but the SGLT-2i [60, 61] and semaglutide [63, 64] CVOTs all reported reduced cardiovascular events for their trial medicines

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