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In a recent study, administration of exendin-4, a long-acting GLP-1RA, stimulated -cell proliferation in juvenile human islets by inducing gene expressions of calcineurin/nuclear factor of activated T cells (NFAT) signaling, a proliferating factor such as NFATC1, and a cell cycle regulator such as cyclin A1 [57]

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They do not explain whether a change came from body fat, muscle mass, water or other components

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This flat-rate model eliminates the financial surprise of climbing to higher doses that plague patients using brand-name medications