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Tirzepatide activates both GIP and GLP-1 receptors, which may produce different neurological effects than pure GLP-1 agonism

Lancet 2021;398:262276.ArticlePubMed 4

(7) Tianqi Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Ya Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang, Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application, Bioactive Materials, Volume 32, 2024, Pages 502-513 (8) Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK

GLP-1 and GIP supplements help by making you feel full, lowering your appetite, and helping the body burn fat better

Significant measurable weight loss typically becomes apparent by weeks 8-12 as the dosage reaches therapeutic levels