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Thus, the decreased cardiorenal risk associated with the combined use of GLP1-RAs/SGLTis may be attributed to an additive effect, achieved by the distinct mechanisms and sites of action for these different drug classes [13]

Pancreatic enzyme evaluation (amylase and lipase), particularly for individuals with predisposing conditions, since mild asymptomatic increases were occasionally observed

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Those with a history of eating disorders or significant gastrointestinal disease may also face additional risks given the drug's potent appetite-suppressing and gastrointestinal effects