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Headache: The most commonly reported adverse event was headache, characterized as mild to moderate in severity

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In a second trial, Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED), a dual SGLT2 inhibitor and gastrointestinal SGLT1 inhibitor sotagliflozin was examined in patients with T2DM, CKD (eGFR from 25 to 60 mL/min/1.73 m 2 ) and CV risk factors

212,213,214 These DAMPs trigger gliotic responses, initially represented by migration of microglia and OPCs as described previously, and second, after the end of infarct expansion, reactive astrogliosis