Major medical organizations such as the American Diabetes Association (ADA) and the Endocrine Society publish clinical guidance on GLP-1 therapy
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The STEP clinical trials demonstrated that semaglutide produced average weight loss of 15% over 68 weeks, while tirzepatide achieved 2022% in similar studies
A meta-analysis showed that exercise training (aerobic and/or resistance exercise and/or high-intensity interval training) led to greater total body mass (mean difference [MD], 1.8 kg) and fat mass (MD, 2.1 kg) losses, but similar lean mass losses (MD, 0.7 kg), compared with controls receiving standard care, following BS [225]