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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]

Archives of Medical Research, 39 (7), 682685

If lean mass was lost during treatment, regain can skew toward fat unless muscle is actively defended