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1 Model based estimates based on an analysis of covariance model including randomized treatment as factor and baseline value as a covariate Missing data were multiple imputed from retrieved subjects of the same randomized treatment arm (RD-MI) in Study 8 or all retrieved subjects regardless of treatment arm assignment in Study 9

doi: 10.1038/nature13949 223 ZhangYLeeFYBarreraGLeeHValesCGonzalezFJet al

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