how does retatrutide Substack Series 3 of 6: – The Next Frontier in Longevity and Metabolic Health What to Know About Retatrutide

Elkind-Hirsch K et al

Semaglutide has been on the market for some time and has shown clinically significant weight loss results, earning it FDA approval under the brand name Wegovy

In 2024 the journal Diabetes named it as a classic paper

Although lowered, the changes observed in subjects treated with either repaglinide or metformin monotherapy were not significant for HbA1C (0.4 and 0.3% decrease, respectively), or fasting plasma glucose (9 mg/dl (0.5 mmol/l) increase and 5.4 mg/dl (0.3 mmol/l) decrease, respectively)

One is to reduce the risk of missing a dose of oral GLP-1 or doubling up on a dose, since each pack corresponds to one dose