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Concurrently, 4-OI reduces the levels of proinflammatory cytokines including TNF- and IL-1 in peripheral blood mononuclear cells and suppresses NF-B activity [63]

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Transcriptional profiling of human (DU145, 22Rv1) and murine (Myc-CaP) PCa cells revealed that IGF-1 suppresses cytokine signalling, antigen processing and presentation, and additional immune regulatory pathways

Adding to the complexity, interferon-gamma (IFNG/IFN-), which is released from CD8 + T cells, downregulates the expression of SLC7A11, effectively promoting ferroptosis induction in HT-1080 and B16 cancer cells [208]

Petersen, J