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While there are no extensive RCTs data that discredit the association of irAEs with good clinical outcomes, a landmark analysis of a retrospective review of only 97 patients showed no difference in OS at 3 months in patients on single-agent ICI, even though the incidence of irAEs was associated with an OS (24.3 versus 5.3 months

Rapid escalation increases side effect severity, particularly nausea and gastrointestinal distress

doi:10.1517/13543784.15.11.1299

Variability and diversity of nasopharyngeal microbiota in children: A metagenomic analysis

For the western blotting of HMGB1, frozen cortices were homogenized in 50 mM TrisHCl (pH 7.5) containing protease inhibitor cocktail and phosphatase inhibitor cocktail