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Below: the standard 8-on/8-off protocol, week-by-week titration math, side-effect-driven adjustments, and how community doses compare to the trial-published 12 mg/week ceiling

Whether men or women lose more lean mass on GLP-1 medications is still unclear, he says

These were generally mild to moderate in severity, most prominent during the dose escalation phase, and tended to diminish over time

The rationale for including them is there, since several have theoretical links to GLP-1 secretion or metabolism

An unexpected finding in our studies was the loss of improved lipid tolerance in Dpp4 EC/ mice, with or without coadministration of sitagliptin, following BMT, implying an interaction between bone marrowderived cells and the metabolic actions emanating from the reduction of DPP-4 activity in endothelial cells