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However, the risk increases significantly when tirzepatide is combined with insulin or sulfonylureas, requiring dose adjustments of these medications

Once thyroid function is stable, thyroid function tests are typically performed annually, but more frequent testing is warranted during active weight loss

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Many women find that the diabetes regimen that worked well for decades starts to feel unpredictable during perimenopause and menopause

Abbreviations HFpEF: Heart failure with preserved ejection fraction HF: Heart failure HFrEF: Heart failure with reduced ejection fraction MetS: Metabolic syndrome T2DM: Type 2 diabetes mellitus SGLT2i: Sodium glucose cotransporter 2 inhibitors GLP-1: RA Glucagon-like peptide-1 receptor agonists GIP: Glucosedependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 BSx: Bariatric surgery NP: Natriuretic peptide NT-proBNP: N-terminal proB-type natriuretic peptid BMI: Body mass index ACC: American College of Cardiology EAT: Epicardial adipose tissue LV: Left ventricular VAT: Visceral adipose tissue IL-1: Interleukin-1 IL-6: Interleukin-6 TNF-: Tumour necrosis factor- DASH: Dietary approaches to stop hypertension SDR: Sodium-restricted LED: Low-energy diet MRPs: Meal replacement plans MedDiet: Mediterranean diet KCCQ-CSS: Kansas city cardiomyopathy questionnaire clinical summary score ET: Exercise training QoL: Quality of life AHA: American heart association RCTs: Randomized controlled trials SET: Supervised exercise training HIIT: High-intensity interval training 6MWD: 6-minute walk distance VO 2 peak: Peak oxygen consumption LIT: Low-intensity training MLHF: Minnesota living with heart failure NNT: Number needed to treat SAE: Serious adverse events AE: Adverse events HFSA: Heart failure society of America ASCVD: Atherosclerotic cardiovascular disease CVOTs: Cardiovascular outcome trials MACE: Major adverse cardiovascular events LVEF: Left ventricular ejection fraction NHE1: Myocardial-specific sodium-hydrogen exchanger 1 AMP: Adenosine monophosphate AMPK: AMP-activated protein kinase ATP: Adenosine triphosphate DNA: Deoxyribonucleic acid ROS: Reactive oxygen species MCP-1: Monocyte chemoattractant protein-1 Ang II: Angiotensin II AT2R: Angiotensin II type 2 receptor ACE2: Angiotensin-converting enzyme-2 NF-B: Nuclear factor-B References Roger VL