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Pharmacokinetic endpoints: if the research objective includes PK characterisation, build in LC-MS quantification of serum peptide at multiple timepoints to generate a concentration-time curve

In SURMOUNT-1, 72 weeks of tirzepatide induced mean WL of 1622.5% in people without diabetes compared to 2.4% with placebo, with no sign of the weight plateauing, suggesting that there may be further WL with long-term use [46]

The dosing protocol is five injections per week into an area of subcutaneous fat, such as an arm, a thigh, or your belly

Doctors don't routinely test for vitamin B12 levels, so vitamin B12 deficiency can go unnoticed