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Other observational studies have linked GLP-1 drugs to lower rates of new and recurring alcohol use disorder, reduced diagnoses and relapse in cannabis use disorder, fewer health care visits for nicotine dependence and lower risk of opioid overdose

The key point is that regain is gradual and can be mitigated with strategic interventions

37 Regulation of the IL-23/Th17 pathway is another possible mechanism of the anti-inflammatory effects of GLP-1RAs

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UCWM (reference category) as the independent variable adjusted for headache frequency at baseline and in a second step also for weight loss to evaluate potential independent treatment effects of GLP-1-RAs