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From a biochemical standpoint, it is classified as a stable gastric peptide, distinct from classical growth factors although it interacts with several of their signaling pathways

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According to the subcellular localization of GSH1, the GSH synthesis initiates in the plastids, but the predominant transcript, especially in the case of multiple GSH2 transcript populations, encodes a cytosolic GSH2, suggesting the second step occurs in the cytosol (Otulak-Kozie et al., 2023)