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Beyond melanin-dependent photoprotection through increased UV absorption by eumelanin, research has characterised MC1R-mediated photoprotection mechanisms that operate independently of melanin production

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62,63 Excess iron is stored in unstable iron pools, which can increase due to metabolic imbalance, leading to increased ROS production through Fenton reactions

The findings were based on an adjusted population of 18,000 patients, out of a total patient population of over 40,000 patients with overweight or obesity initiating either semaglutide or tirzepatide between May 2022 and September 2023

Key Takeaways and Clinician Discussion Points The safest way to interpret GHK-Cu peptide is through route, evidence quality, regulatory status, safety data, and clinician-guided decision-making