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Mounjaro, differing in its approach, utilizes tirzepatide as its active ingredient, targeting both GLP-1 and GIP receptors, which may, in some cases, enable more significant weight loss compared to Semaglutide GLP-1-based treatments

Studies in mice suggest that GIP may potentiate the GLP-1-induced reduction of food intake and body weight by enhancing POMC expression and neuronal activation within distinct neuron populations in the hypothalamus (149)

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Recent evaluations by regulatory agencies and large-scale studies provide further clarity