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Icotrokinra Description and Review of Available Data Icotrokinra is a chemically synthesized cyclic peptide (molecular weight, 1.9 kDa) that binds selectively to the IL-23R, thereby blocking IL-23 signaling and the subsequent production of downstream cytokines, including IL-17A, IL-17F, and IL-22 [80] (Fig

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While useful and still heavily relied upon, these traditional batch synthesis approaches can suffer from significant issues including complex impurity profiles due to incomplete reactions or double-addition, and significant challenges accessing difficult sequences [7], such as highly hydrophobic peptides that are prone to aggregation

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