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45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization

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Semaglutide, a GLP-1RA, has been linked to reduced rates of MACE, including heart attacks and strokes, in patients with diabetes [31, 32]

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