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Of note, a recent meta-analysis encompassing those clinical trials focused on the cardiovascular safety of GLP-1 RAs found significant reductions in MACE3 (a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke), hospitalization for heart failure and progression of chronic kidney disease [8]

Additionally, elevated intracellular calcium levels open up mitochondrial pores, resulting in the dissipation of electrochemical gradient and formation of new ATPases (40)

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Although we need human studies to conclude with any certainty, taking certain probiotic strains could theoretically help improve histamine intolerance 13