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Upon systemic injection, MOG-MSNs accumulate in CD11c+ dendritic cells, F4/80 + macrophages, and B220 + B cells, where slow release of peptide undercuts costimulatory molecule upregulation and favors semimature, tolerogenic APC phenotypes

This temperature sensitivity necessitates comprehensive cold chain logistics planning for international shipments, particularly for deliveries to regions with challenging climate conditions or limited refrigeration infrastructure

Zealthy's compounding partnerships also allow dose adjustments that reduce per-dose costs

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