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Bioavailability is the most critical factor

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The possible association of MEL with hepatic steatosis is based on historical observations that showed that pinealectomy increased serum glucose levels in laboratory animals, while administration of MEL corrected these abnormalities (100, 101)

Elevating LPCAT3 mRNA levels can mitigate chondrocyte ferroptosis in OA, and its enzymatic activity correlates with local inflammatory levels