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It downregulates NF-B signaling, reduces pro-inflammatory cytokine production (TNF-, IL-1, IL-6), inhibits mast cell activation, and has demonstrated mucosal protective effects in colitis models

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Necrosis, in divergence, represents uncontrolled cell death, characterized by cell enlargement, membrane rupture, and the release of intracellular contents, leading to inflammation (Bertheloot et al., 2021)

(2023) found that while significant weight loss was achievable with GLP-1s among type 2 diabetes patients, the average weight reduction was relatively modest (2.2% over 72 weeks)

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