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Vehicle-treated mice displayed severe islet disorganization and loss of insulin-positive -cells

Practitioner-reported protocols commonly reference doses of 20-100 mcg per injection site

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Finally, host-directed therapies that modulate immune responses, such as targeting host cytokines (e.g., IL-10, TGF-) or enhancing macrophage leishmanicidal activity, represent a promising complementary approach (Kumar et al., 2017)