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More than 90% of dietary TRP is metabolized via the KP, primarily in the liver [171], generating circulating KYN that readily crosses the BBB, whereas downstream metabolites such as KYNA, QA, and 3-HAA remain largely trapped within the CNS once synthesized [20]

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These enzymes are involved in glycolysis, oxidative decarboxylation of pyruvate to acetyl-CoA, the tricarboxylic acid cycle, -oxidation of fatty acids, and alcohol metabolism