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Why Controlling 40-3 Impurities Is Critical for API Quality There is a significant risk of introducing three key impurities during the synthesis of the 40-3 fatty acid side chainmono-AEEA, tri-AEEA, and -alanine (-Ala) (see structures below)

An additional set of blots of nitrated bovine serum albumin (BSA) showed an immuno-positive response to anti-nitroY mAb while not to anti-nitroY250-HGF mAb, and hence served as a control and demonstrated high immuno-specificity of the anti-nitroY-HGF used here

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Together, these factors significantly raise the risk of heart disease, stroke, and other cardiovascular problems

PMCID: PMC7933196