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Experimental research suggests that salidroside may normalize cortisol responses, improve glucocorticoid feedback regulation, reduce CRH and ACTH signaling, protect stress-sensitive brain regions, support neurotransmitter balance, and mitigate inflammation and oxidative damage

The formation of tioether adducts with quinones resulting from the auto-oxidation of the MDMA catechol type metabolites HHMA and HHA (3,4-dihydroxyamphetamine) is one of the hypotheses for MDMA induced neurotoxicity

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