Accumulation of ethanol-associated reactive molecules, e.g., reactive oxygen (ROS) and nitrogen species (RNS), and electrophilic products, e.g., acetaldehyde and lipid peroxidation-derived products, can be harmful to biological systems due to their propensity to inactivate enzymes, leading to loss of protein function, DNA damage and cell death 4
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These defense mechanisms depend in a great part on the metabolic supply of the reduced form of NADP (NADPH + H+)
org/10.2174/1389200216666151015114515 Hristov, B