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Individuals with diabetes have a higher risk of myocardial infarction (MI), which is more common and carries an increased likelihood of complications and recurrent events compared to those without diabetes

Retatrutide (LY3437943) is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors simultaneously that has not received UK marketing authorisation from the MHRA or approval from the EMA

As the WL achieved with the novel obesity pharmacotherapies approaches that of bariatric surgery, we will need to assess whether long-term complications observed after bariatric surgery such as increased risk of osteoporosis, fractures, macro- and micronutrient deficiencies as well as self-harm behaviours will also be present with pharmacotherapy [112, 113]

we chose a suitable comparator group

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