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Given that the IC 100 concentration of niclosamide required to completely prevent viral replication in SARS-CoV-2 infected Calu-3 lung cells as measured by Ko et al (34) as 2M, a 20uM niclosamide solution nasal spray is 10x this IC 100

The total weight loss for these combination drugs ranges from 6.4 to 9.8% of the initial body weight

Asimakidou, Evridiki, Richard Reynolds, Anna M