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Reduced Akt activity alleviates inhibition of FoxO, a transcription factor that upregulates the expression of the muscular atrophy factor (atrogin-1/MAFbx), and the upregulation of muscle atrophy factor accelerates muscle atrophy (68)
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mRNA vaccines use lipid nanoparticle delivery, which triggers immune activation with minimal excipients but carries a risk of PEG-induced allergies
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The more signaling pathways an active ingredient influences, the more relevant controlled clinical trial data, long-term observation, and regulatory review become
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