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As the disease progresses to the inflammatory phase, alkaloids (e.g., berberine) and terpenoids (e.g., tanshinone IIA) synergistically regulate lipid metabolism and inflammation through pathways such as AMPK/NF-B and PPAR- (Fang et al., 2022a

"With the approval of Opzelura in nonsegmental vitiligo, Incyte has once again delivered a treatment to patients with high unmet medical need who previously had no approved therapies," Herv Hoppenot, Incyte's chief executive officer, said in a press release

However, activation of caspase-3 was not essential for the execution of apoptosis-like cell death of RBCs, resulting in the hypothesis that caspases were required for appropriate erythropoiesis [23]