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The mitochondrial membranes are rich in polyunsaturated fatty acids, making them highly susceptible to a specific type of oxidative damage known as lipid peroxidation

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470 In animal models of Apelin-13-caused cardiomyocyte hypertrophy and heart failure, NCOA4-activated ferritinophagy leads to the upregulation of SFXN1 expression, causing mitochondrial iron overload and mitochondrial ROS overproduction, increased lipid peroxidation, and ultimately, ferroptosis

Although sex is a crucial biological variable, the limited representation of males with LC compared to females in our cohort prevented us from observing any significant differences