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2000, 139: S124-130

The risk-benefit calculation strongly favors semaglutide for most patients, particularly those with existing cardiovascular risk factors

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In humans, PAGln enhances platelet reactivity and thrombotic potential through ADR signaling, accelerating thrombus formation in arterial injury models while promoting systemic inflammation and endothelial dysfunction to drive atherosclerosis ( and promote M1 macrophage polarization, accelerating atherosclerosis