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Muscle cramps during GLP-1 therapy are typically caused by indirect factors including electrolyte depletion (especially magnesium and potassium) from gastrointestinal side effects, dehydration from reduced fluid intake or vomiting/diarrhea, rapid weight loss with some lean mass reduction, and increased physical activity exceeding current conditioning levels
Blood sugar levels can rise again if treatment is stopped, so your prescriber should guide any changes
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Compared to natural ligands, retatrutide shows lower potency at GLP-1 and glucagon receptors but higher potency at GIP receptors
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