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Example 11 Synthesis of semaglutide: 100mg of compound 4 obtained in example 7 with a purity of about 74.08% was added to an iced freshly prepared 1mL of lysate (trifluoroacetic acid: water: triisopropylsilane =95 2

Early clinical trials have shown promising results, with agents like semaglutide and exenatide demonstrating reductions in alcohol consumption and craving, as well as potential benefits for smoking cessation, such as reduced post-cessation weight gain

Claus SP, Guillou H, Ellero-Simatos S

The most common side effects of GLP-1 agonists are gastrointestinal: nausea, vomiting, diarrhea, and bloating

D., Butts, C