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Under conditions where antioxidant and iron-buffering systems are adequately engaged, NRF2 activation enhances GPX4, superoxide dismutase (SOD), and GSH levels, reduces lipid hydroperoxides, malondialdehyde (MDA), and ROS accumulation [118], and thereby suppresses ferroptotic cell death
[8] [9] For some patients, intensification of insulin therapy may be necessary
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Diabetes Metab Syndr 2022;16:102640.ArticlePubMed 14
While mature cardiomyocytes may be protected against DOX-induced apoptosis downstream of mitochondrial outer membrane permeabilization (MOMP), the lack of MOMP induction can alter metabolic phenotype and induce hypertrophic remodeling
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