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Most users begin noticing skin firmness improvements within 4 to 8 weeks of consistent subcutaneous administration, with optimal results typically appearing after 12 weeks of use

doi: 10.1186/s40168-024-01964-0 121 ZhouWWuWSiZLiuHWangHJiangHet al

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There are a few reasons you start on this small dose: Reduces Side Effects: common side effects include nausea, bloating, constipation, or diarrhea, and a smaller dose minimizes uncomfortable side effects, which lessen over time

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